Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats
نویسندگان
چکیده
منابع مشابه
P59: Effect of Umbelliprenin on Behavioral Responses of Neuropathic Pain and the Expression of Inflammatory Factors in Chronic Constriction Injury Model of Neuropathic Pain in Male Rats
Despite extensive investigations, the main mechanisms underlying neuropathic pain development are still not fully understood and there is no effective treatment for that. So intensive research is being done for finding new, efficient analgesic drugs. 56 male Wistar rats (230±30) were divided into 7 groups (n=8); control, sham, CCI and 3 Umbelliprenin groups (25, 50 and 100 microgram/rat)...
متن کاملEffects of combined chronic progesterone administration and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats
Introduction: Neuropathic pain is a chronic pain that results from damage to the central and peripheral nerves. According to the previous studies, physical activity or progesterone can be an effective treatment for alleviating sensory neuropathic pain individually. In this way, the combined effect of chronic progesterone and forced exercise on behavioral pain responses in the neuropathic pain m...
متن کاملEffects of co-administration of chronic curcumin and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats
Introduction: Neuropathic pain is a chronic pain that results from damage to the central and peripheral nerves. According to the previous studies, curcumin and exercise can be effective treatments for alleviating sensory neuropathic pain individually. Now the combined effect of chronic curcumin (Cur) and forced exercise on behavioral pain responses in the neuropathic pain model of chronic const...
متن کاملP 15: Forced Exercise Attenuates Neuropathic Pain in Chronic Constriction Injury Male Rat: An Approach to Oxidative Stress and Inflammation
Introduction: Peripheral and central nerve injuries cause chronic neuropathic pain in many injured people besides motor disability. Exercise, as a behavioral and non-pharmacological treatment, has beneficial effects on people’s general health both for healthy and sick people. Therefore, this study was conducted to examine the effects of exercise on neuropathic pain induced by chronic cons...
متن کاملSodium Hydrosulfide Relieves Neuropathic Pain in Chronic Constriction Injured Rats
Aberrant neuronal activity in injured peripheral nerves is believed to be an important factor in the development of neuropathic pain (NPP). Channel protein pCREB of that activity has been shown to mitigate the onset of associated molecular events in the nervous system, and sodium hydrosulfide (NaHS) could inhibit the expression of pCREB. However, whether NaHS could relieve the pain, it needs fu...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2018
ISSN: 1663-9812
DOI: 10.3389/fphar.2018.00989